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History and Studies
- 2018~2013
- 2012~2007
- 2006~2002
- 2001~1981
2018
Research paper
• Subchronic Oral Dose Toxicity Study of Enterococcus Faecalis 2001 in mice (Toxicol. Res. Vol 34)
2017 _ Established BeRM International
Research paper
• The role Supplement EF-2001 Containing Enterococcus faecalis on murine ileal immune responses (Pharmacometrics 93(5/6)
• Pharmaceutical production of Anti-tumor and immune-potentiating Enterococcus faecalis -2001 β-glucns:Enhanced Activity of Macrophage and Lymphocytes
in Tumor-implanted Mice (Current Pharmaceutical Biotechnology, 2017,18,653-661)
• FSSC 22000 CERTIFICATION
• "Prevention and Improvement of Muscle Reduction Using Heat killed probiotics EF-2001" (Ministry of Industry and Trade, Yonsei University)
• Acquired the Korean patent (No. 10-1800632), applied international patent (No. PCT / KR2017 / 011557) "Pharmaceutical composition,
food composition and food additive for the prevention, improvement or treatment of muscular dysfunction,
weakening and muscle atrophy comprising an enterococcus faecalis, a culture solution or dead cells as an active ingredient" Vietnam food raw material
registration Established ‘BeRM International’
2016 _ Atopy ameliotation of Heat killed probiotics EF-2001
Research paper
• Atopy ameliotation of Heat killed probiotics EF-2001
• Heat-killed Enterococcus faecalis EF-2001 Ameliorates Atopic Dermatitis in a Murine model (Nutrients,2016,8,146)
• Effect of Enterococcus faecalis EF-2001 on experimentally induced Atopic Eczema in Mice (Food Sci. Biotechnol.25(4):1-7(2016))
• Completion of high-concentration heat-killed probiotics laboratory and production plant (Wonju, KOREA)
• Contracted with Yonsei University(Prof. Kim Taek-jung) for researching physiological activity
• MOU with Shanghai BeRM
• Yonsei University Scholarship / Development Fund Donation (100 million won)
2015 _ Selected as the leading company for high technology in food industry
Research paper
• (Ministry of Strategy and Finance) probiotics sector
(7.5 trillion billion probiotics production technology and EF-2001 strain)
2014 _ Candidasis protection of Heat killed probiotics EF-2001
Research paper
•Protection of Mice from Oral Candidasis by Heat-killed Enterococcus faecalis, possibly through its Direct binding to
Candida albicans (Med.Mycol.J.-Vol.55E)
• Effect of Enterococcus faecalis EF-2001 on experimentally induced Atopic Eczema in Mice
(Food Sci. Biotechnol.25(4):1-7(2016))
• Established R & D Center in Korea
• contracted with Professor Kim Eun-kyung of Konkuk University for research on physiological activity
2013
• Innovation Award nomination from Sial Middle East
2012 _ Normalization of skin mucous membranes of Heat killed probiotics EF-2001
Research paper
• Radioprotection effect and immune activity by Enteroccocus Faecalis 2001 (16th International Oriental Medicine Society)
• Normalization of skin mucous membranes of Heat killed probiotics EF-2001 (16th International Oriental Medicine Society)
2011 _ Normalization of skin mucous membranes of Heat killed probiotics EF-2001
Research paper
• Usefulness of probiotics in the Treatment of Infectious Diseases
(Efficacy of Heat killed probiotics EF-2001 on Ulcerative Colitis and Normalization of Cytokine
(Antitumor Effect of EF-2001 and NK Cell Activation Activity) (Japanese Society of Medical Systems magazine vol.17 No.1 2011)
Medical Society presentation
• Radionprotection effect and immune activity by Enteroccocus Faecalis 2001
(14th International Congress of Radiation Research_Poland)
2010 _ Established KOREA BeRM co.ltd
Medical Society presentation
• Effectiveness of Heat killed probiotics EF-2001, Ulcerative Colitis and normalization of cytokine
• Antitumor effect of Heat killed probiotics EF-2001 and activation of NK cells
(Japanese Society of Medical Systems Academic Conference)
Immuno-activation and Radioprotection Effect by Enterococcus Faecalis 2001 (2010 international Conference)
2009_The Radiation Protection and Anticancer Effect of β-glucan Derived from Enterococcus faecalis EF-2001
Medical Society presentation
• The Radiation Protection and Anticancer Effect of β-glucan Derived from Enterococcus faecalis EF-2001
Studies on the Radiation Protection and Anticancer Effect of β-glucan Derived from Enterococcus faecalis EF-2001
(The 52nd Annual Meeting of the Radiation Effects Society of Japan)
• Radiation protection and immune-stimulatory effect by β-glucan derived from Enterococcus faecalis EF-2001(2nd Asia Radiation Workshop)
•Studies on the Antidiabetic Effect on Saponin and Lactic Acid (Ef-2001) (The 129th Annual Meeting of the Japanese Pharmacovigilance Association)
2008_Leukocyte activity and body defense effect
Research paper
• Antitumor effect and antioxidant effect by mixture of water soluble propolis (WSP) and probiotics EF-2001
(Medicine Biology, Vol.152. No.5)
Medical Society presentation
• Radioprotection and Antitumor Effect by β–D-glucan (Japanese Cancer Society)
• Immune resurgence (2nd Japan Radiation Protection Research Meeting)
• Antitumor effect and antioxidative action of mixture of water extract propolis and EF-2001 (Japanese Pharma society)
• Antitumor effect and radiation protection effect (KSEAJ 15th Academic Conference)
2007_Radiation Protection Effecct for Enterococcus Faecalis 2001
Research paper
• Study on antihyperlipidemia of Heat killed probiotics EF-2001 (Medicine Biology Vol 151, No10)
• Radiation Protection Effecct for EF-2001(Enterococcus Faecalis 2001) (Medicine Biology 151(9))
Medical Society presentation
• Effects on lifestyle-related diseases (International Oriental Medicine Society)
• Antitumor effect (The 66th Japanese Society of Cancer_ Japan)
• Effects on hyperlipidemia (Japanese Pharmacy Society)
• Antioxidative action of water extract propolis and EF-2001 (Japanese Pharmacology Association)
• Radioprotection effect and anit-tumor immunity by enterococcus faecalis 2001 in mice
(13th international congress of Radiation Research, USA)
• Support to Africa Ghana Orphanage / School / Youth Soccer team (SWEDRU ALL BLACKS F.C)
2006_Effects on hyperlipidemia
Medical Society presentation
• Effects on hyperlipidemia (International Oriental Medicine Society)
• Radiation Protection Effects (The 49th Annual Meeting of the Radiation Effects Society of Japan)
2005_ Combined effect of CyberKnife and EF2001 in the treatment of liver cancer
Medical Society presentation
• Radiation Protection and Immune Enhancement Effect (The 48th Annual Meeting of the Radiation Effects Society of Japan)
• Combined effect of CyberKnife and Heat killed probiotics EF2001 in the treatment of liver cancer
(2005 European Cancer Society _ France)
• Immune enhancement and radiation protection effect (International Oriental Medical Association 2005)
• Diabetes Improvement Effect (Japanese Pharmacy Society)
2004_2004 Improvement of quality of life (QOL) of patients with cancer treated with radiation therapy of Heat killed probiotics EF-2001
Medical Society presentation
• Radiation Protection Effects (2004 Symposium on Radiation Protection and Radioactive Waste)
• Anti-diabetic effect (The 34th Japan East Asian Medical Congress Donghae Branch General Meeting)
• Antitumor effect and radiation protection effect (The 63rd Japan Cancer Society)
• Radiation Protection and Immune Enhancement Effect (International Oriental Medicine 2004)
• Antitumor Effect and Radiation Protection Effect of Propolis EF-2001 Compound (The 55th Japan Oriental Medicine Society)
• Improvement of quality of life (QOL) of patients with cancer treated with radiation therapy of Heat killed probiotics EF-2001
(9th International Hyperthermia Tumor Society, USA)
• Studies on Liquid Immunity and Radiation Protection (The 63rd Annual Meeting of the Japanese Radiological Medicine Society)
• Anti-diabetic effect (Japan Pharmaceutical Society)
• Antitumor effect, analgesic effect, radiation protection effect (Korean anti-aging conference)
2003_Anti-allergic effect and immune-stimulating effect
Medical Society presentation
• QOL (quality of life) improvement effect by radiotherapy cancer patients
(The 46th Annual Meeting of the Japanese Radiation Effects Society)
• Anti-allergic effect and immune-stimulating effect (The 62nd Annual Meeting of the Society of Radiation Effects)
• Antitumor, Radiation Protection Effect (International Korean Medical Association 2003)
• Anti-inflammatory effect of Propolis combination with EF-2001
(9th cancer treatment improvement study meeting Japan)
• Anti-allergic effect (Japan Cancer Society)
2002_Clinical trial among cancer patients taking probiotics with hyperthermia treatment
Research paper
• Effect of Enterococcus Faecalis EF-2001 on Intravenous Infection and Foot Edema in ICR Mouse(Medicine Biology Vol 144, No 1)
Medical Society presentation
• Antiallergic effect (International Oriental Medicine Association)
• Clinical trial among cancer patients taking Heat killed probiotics EF-2001 with hyperthermia treatment
(3rd International Conference on Anti-Aging Medicine _ Monte Carlo)
2001_A biological response modifier and enhancing a biological response control function
Obtained patent
• a biological response modifier and enhancing a biological response control function (Japanese Patent No. 3151442)
Research paper
• Antitumor effect of water-soluble extracts derived from Enterococcus faecalis EF-2001 ( Medicine Biology, Vol. 143, No. 3)
• Physiological effects of heat-treated probiotics EF-2001 and its application to food (Food Industry Vol.44)
Medical Society presentation
• Effect on intestinal bacteria, immune enhancement effect (International Society for Microbiology_Holland)
• Protection effect of skeletal malformation of radiation (The 41st Japanese Society of Congenital Anomalies)
• Biological Response Modifier Action (11th Or-ring Test Society)
2000_Elimination Promotion of Escherichia coli of Heat killed probiotics EF-2001
Research paper
• Elimination Promotion of Escherichia coli of Heat killed probiotics EF-2001 (Medicine Biology, Vol 140, No 3)
Medical Society presentation
• Tumor Suppression Effect (The 13th Biotechnology Society)
• Radiation protection effect (Japan Radiation Effects Society), (6th International Conference on Congenital Anomalies)
• Effectiveness in HIV patients (4th International Symposium on O-ring Testing)
• Antitumor effect(Japanese Pharmacological Society)
1999_Increase of lymphocyte / polymorphonuclear leukocyte ratio
Research paper
• Serum Academic Confirmation of Heat-killed Entrococcus faecalis EF-2001 (Medicine Biology, Vol. 139, No. 2)
Medical Society presentation
• Increase of lymphocyte / polymorphonuclear leukocyte ratio (Japan Pharmacy Society)
1998_Antitumor effect and analgesic action
Medical Society presentation
• Antitumor effect and analgesic action (Japanese Pharmacology Association)
1995_Established BeRM company
• Production of Heat killed probiotics EF-2001
1984_Started research on Heat killed probiotics
• Initiation of study on Enterococcus feacalis EF-2001, a high-concentration heat-killed probiotics
1982_probiotics study
• FK23 probiotics study
1981_Started research on probiotics
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