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 We need technologies to kill probiotics.

 

 

Counterattack of Dead Probiotics

 

The definition of probiotics has been gradually expanding over time.

 

In 1989, Fuller defined probiotics as "microorganisms that have beneficial effects on the host by improving the intestinal flora", and it was established as living microorganism.

 

In 1999, Salminen et al. defined it as "microorganisms or components of microorganisms that have beneficial effects on a host", so the scope of probiotics was expanded to include dead bacteria and its components.

 

The dead probiotics is the opposite concept of live probiotics, and they don’t grow or metabolize in our body any more by heat treatment.

 

Bacterial components such as cytoplasm or cell wall stimulate immune cells in the intestine activating immune systems and have effects such as aggregating with harmful bacteria without any side effects.

 

The dead probiotics products have high stability compared to live bacteria products. In particular, they have excellent heat resistance and high stability to the external environment, so it is easier to store than existing probiotics products with an advantage of extending the shelf life.

 

Therefore, the dead probiotics product can be applied as a cosmetic raw material, besides to the fields where the existing live probiotics have been applied in, such as health functional foods, food additives, pharmaceuticals, and animal feed.

 

In addition, as the regulations on the use of antibiotics are strengthening, the growth potential of the market about antibiotic substitute using bacterial substances is very high.

 

In particular, many dead probiotics products have already been released in Japan, and are being promoted based on immunity-related efficacy such as pollen allergy.

 

There are many ways to kill bacteria such as an ultrasonic, gamma ray irradiation, UV irradiation, and heat treatment, among which the easiest and safest method is heat treatment (Tyndallization).

 

Then, if you cultivate the bacteria and keep only a certain sterilization time at a certain sterilization temperature, can you make best dead probiotics?

 

Way to Make Best Dead Probiotics

 

Excellent dead probiotics is a material that has been killed in a state that can maximize efficacy while being safe.

 

If it is said that dead cells are manufactured by safe heat treatment, the most important thing is the heat treatment time and temperature.

 

You might think that you can just put it at a high temperature for suitable time to kill the bacteria, but physiological activities such as immune activity can change depending on the sterilization temperature and time.

 

This is because useful microbial components can be changed by heat treatment, and there is a report that when sterilizing certain microbial cells at a specific temperature, the immunity activity is rather increased, and various patents have also been applied for the heat treatment probiotics manufacturing method.

 

In addition, if the treatment temperature and time are too low, the killing may not be performed properly, and a method of increasing the cell recovery rate is a technique, and through this, raw materials with a high cell content (concentration) can be produced.

 

The heat-treated probiotics of CUOME is made without destroying the effective ingredients, and recover the bacteria at a high concentration, so that you can safely consume high-quality heat-killed probiotics.